Computational Bioengineering

A Study on Cancer Cell invasion and the Chemotherapy Process 

with a Three-dimensional Dynamic Multi-scale Model 

The current study of cancer cell invasion has mainly performed with the experimental approaches, and it has focused only on the taxis mechanism. These induce difficulties in cancer cell research due to the impractical expense and time. Hence, the development of a comprehensive cancer cell model that incorporates important mechanisms will lead the highly efficient cancer cell study. Therefore, we propose a three-dimensional dynamic multi-scale model that simulates cancer cell invasion and chemotherapy, which will allow us to develop prediction techniques based on the quantitative investigation of cancer cell invasion and the chemotherapy process. 

Fig 1. The degraded evolution of the ECM and The distributions of MDEs when the rate of MDEs release by cancer cells

Fig 2. The evolution sequence of chemotherapeutic drug diffusion and Morphological changes of cancer cells are affected without chemotherapeutic drug and cancer cells are affected by chemotherapeutic drug 

Fig 3. Multiscale analysis to estimate interface energy at the cell membrane on Molecular Dynamics 

Fig 4 .Evolution sequence and morphological change of a crawling cell in the chemotactic condition. The cell is subjected to the linear chemoattractant gradient field where a is 3.5. 

Fig 5. Evolution sequence of a crawling cell on the geometrically patterned substrates. The cell is subjected to the linear chemoattractant gradient field where a is 3.5